Enabling Comprehensive Assessments of Drug–Drug Interaction Risks

Understanding the dynamics of drug metabolizing enzymes and transporters (METs) is critical to successful drug development. MET behavior can significantly impact drug safety. Many factors regulate enzymes and transporters, which in turn affect the pharmacokinetic properties of drugs and mediate drug interactions. Evaluation of drug interaction profiles required detailed in vitro and in vivo studies along with predictive modeling. Thanks to its comprehensive data on METs, PharmaPendium offers a unique platform for modeling advanced drug interactions. This MET data and the ability to predict drug–drug interactions (DDIs) are incredibly valuable for optimized research workflows and accelerated drug development. They enable intelligent, in silico drug design and provide scientists with comprehensive knowledge about drug metabolism, significantly reducing the need for costly and time-consuming lab work and animal models and informing critical decisions on clinical trial design.